Overview
| Product name | DNMT3A Antibody (Center) |
| Catalog no | 4ab031013 |
| Size | 100 μl |
Applications
| Description | 4ab031013|DNMT3A Antibody (Center) |
| Reactivity | Human |
| Immunogen | This DNMT3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 463-497 amino acids from the Central region of human DNMT3A. |
| Host | Rabbit |
| IsoType | Rabbit Ig |
| Clonality | Polyclonal |
| Application | WB |
| Conjugate | Unconjugated |
| Background | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
image of DNMT3A Antibody (Center)
¥800.00
DNMT3A Antibody (Center)
规格：
货期：现货
