IL-12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDA (p40) subunit and a 35 kDa (p35) subunit.the p40 subunit shared by interleukins 12 and 23.IL-12 is produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells. It has multiple effects on T-cells and NK cells, including stimulation of cytotoxic activity, proliferation, and promotion of Th1 development as well as IFN-gamma and TNF productio. IL-23 is mainly secreted by activated dendritic cells, macrophages or monocytes.IL-23 is suspected to play a role in tumorigenesis.

Cell Surface Flow Cytometry Staining Protocol

1、Vsn, M. et al. (2016) VALUE IN HEALTH 19 PSS5:A123